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³§°Õ·¡²Ñ±è°ù±ð±èâ„¢ Tissue Dissociator | Automated Tissue Dissociation for High-Quality Single-Cell Suspensions

Research and development in various fields, including cancer and immunology, rely on single-cell suspensions for use in applications such as flow cytometry and single-cell sequencing. Effective tissue dissociation methods are needed to generate single-cell suspensions with high viability. However, conventional manual dissociation methods can be labor-intensive, inconsistent, and prone to variability, all of which can negatively affect reproducibility and data accuracy.

To address these challenges, we developed the ³§°Õ·¡²Ñ±è°ù±ð±èâ„¢ Tissue Dissociation System—an automated solution that standardizes and streamlines the dissociation process. With built-in temperature control, modular scalability, and an intuitive interface, ³§°Õ·¡²Ñ±è°ù±ð±èâ„¢ ensures efficient, reproducible, and high-yield single-cell suspensions from a wide range of solid tissues while preserving epitope integrity and cell functionality.

Why Use ³§°Õ·¡²Ñ±è°ù±ð±èâ„¢?

  • Standardize tissue dissociation with automation for consistent, reproducible results.
  • Obtain high numbers of viable single cells with preserved functionality for downstream applications.
  • Ensure optimal sample processing for various sample types and applications with built-in temperature control from 4 to 37°C.
  • Choose from a 4-sample, 8-sample, or 12-sample system—scaling seamlessly to meet increasing throughput needs while maintaining efficiency.
  • Use validated º£½ÇÆÆ½â°æ protocols or create your own to adapt ³§°Õ·¡²Ñ±è°ù±ð±èâ„¢ to different tissue types and experimental needs.

³§°Õ·¡²Ñ±è°ù±ð±èâ„¢ Products

³§°Õ·¡²Ñ±è°ù±ð±èâ„¢ Tissue Dissociator

Description:

³§°Õ·¡²Ñ±è°ù±ð±èâ„¢ Tissue Dissociator is an automated, modular system for generating high-yield, high-viability single-cell suspensions. It combines mechanical and enzymatic dissociation under controlled conditions, reducing user variability and manual effort. With built-in temperature control (4 - 37°C) and a user-friendly touchscreen, it ensures optimal, reproducible results. Designed to work with ³§°Õ·¡²Ñ±è°ù±ð±èâ„¢ Sample Tubes and Dissociation Kits, the system scales from 4 to 12 samples with Primary and Secondary Units, and up to 16 with an optional Expansion Unit.

Advantages:

  • Standardize tissue dissociation for consistent, reproducible results.
  • Achieve high numbers of viable, functional single cells.
  • Maintain optimal processing with temperature control from 4 to 37°C.
  • Start with a 4-, 8-, or 12-sample system and scale as needed.
  • Use º£½ÇÆÆ½â°æ protocols or create your own for various tissue types and needs.

Size:

4-Sample System
8-Sample System
12-Sample System

Note: If you need to go beyond the 12-sample system, you can purchase an additional Expansion Unit to increase sample capacity by 4.

³§°Õ·¡²Ñ±è°ù±ð±èâ„¢ Tissue Dissociation Kits

Description:

Each ³§°Õ·¡²Ñ±è°ù±ð±èâ„¢ Tissue Dissociation Kit includes an optimized enzymatic cocktail formulated to gently dissociate tissue while preserving cell viability and functionality. When used as part of the ³§°Õ·¡²Ñ±è°ù±ð±èâ„¢ system, it streamlines workflows and produces high-quality samples suitable for downstream applications such as cell separation, culture, phenotyping, and molecular analysis.

Advantages:

  • Achieve reproducible tissue dissociation when used with the ³§°Õ·¡²Ñ±è°ù±ð±èâ„¢ Tissue Dissociator
  • Ensure gentle yet effective tissue processing by combining enzymatic digestion and mechanical dissociation
  • Generate reliable single-cell suspensions
  • Obtain high numbers of viable cells

Size:

50 preparations

³§°Õ·¡²Ñ±è°ù±ð±èâ„¢ Sample Tubes

Description:

³§°Õ·¡²Ñ±è°ù±ð±èâ„¢ Sample Tubes are single-use tubes made for the ³§°Õ·¡²Ñ±è°ù±ð±èâ„¢ Tissue Dissociator and compatible kits. They enable standardized, efficient mechanical tissue dissociation across various sample types. Each tube includes a blade-integrated reservoir, central rotor, and secure lid, and is ready for immediate use. Once installed, the rotor provides controlled, reproducible dissociation—minimizing manual variability and streamlining workflows.

Advantages:

  • Enable reproducible tissue dissociation with the ³§°Õ·¡²Ñ±è°ù±ð±èâ„¢ Tissue Dissociator
  • Support a wide range of input sizes (20 - 4000 mg) and volumes (1 - 10 mL)
  • Minimize user variability for consistent downstream results
  • Protect sample integrity with single-use format

Size:

25 sample tubes
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Seamless Integration into Your Workflow

³§°Õ·¡²Ñ±è°ù±ð±èâ„¢ integrates with º£½ÇÆÆ½â°æ Technologies’ tissue processing and cell isolation solutions, enabling an end-to-end workflow. Resultant cell suspensions can be used with ·¡²¹²õ²â³§±ð±èâ„¢ for column-free cell isolation; ±õ³¾³¾³Ü²Ô´Ç°ä³Ü±ô³Ùâ„¢ immune cell culture media, activators, and supplements; or other º£½ÇÆÆ½â°æ reagents to maximize cell purity and recovery.

Figure 1. ³§°Õ·¡²Ñ±è°ù±ð±èâ„¢ Tissue Dissociation Workflow

The ³§°Õ·¡²Ñ±è°ù±ð±èâ„¢ Tissue Dissociator enables efficient processing of various tissue types, including mouse brain, liver, lung, spleen, and tumors. In this workflow, a tissue is placed into the ³§°Õ·¡²Ñ±è°ù±ð±èâ„¢ sample tube and processed using the ³§°Õ·¡²Ñ±è°ù±ð±èâ„¢ Tissue Dissociator. Depending on the selected protocol—dissociation or homogenization—the resulting sample will either be a single-cell suspension or nucleic acids. The processed sample can then be used for various downstream applications, such as cell isolation, activation, culture, and analysis.


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