Human Leukocyte Antigen Analysis

Human leukocyte antigen (HLA) molecules are highly polymorphic membrane proteins that play a central role in immune recognition and compatibility. In transplantation diagnostics, differences in HLA expression between donor and recipient can lead to immune rejection, making accurate HLA typing and crossmatch testing essential for successful outcomes. Advances in molecular methods such as next-generation sequencing (NGS) now enable high-resolution HLA genotyping and sensitive chimerism monitoring. These technologies allow laboratories to detect subtle genetic variations and monitor HLA chimerism or loss of heterozygosity (LOH), both of which can have critical implications for transplant success and relapse detection^1,2.

In an era where virtual crossmatch and antibody profiling tools are expanding, physical crossmatch testing remains a vital and complementary tool for confirming donor-recipient compatibility³. ��ƽ�� supports these workflows with reliable cell isolation and enrichment solutions that help your laboratory perform accurate, reproducible HLA analysis with confidence.

Below, explore a curated collection of educational resources that highlight best practices, innovations, and expert insights in HLA testing, crossmatch analysis, and chimerism monitoring.