T Cell Therapy
Adoptive T cell therapy has brought excitement to immuno-oncology research and hope to cancer patients who are out of treatment options. The most popular form of T cell for therapy are chimeric antigen receptor (CAR) T cells. These cells are engineered to express a synthetic transmembrane receptors containing the variable domain of an antibody to redirect their specificity to recognize and eliminate cancer cells upon infusion in patients.
Below is a collection of scientific resources for your T cell therapy research.
Rational Combination of Cancer Therapies with PD1 Axis Blockade
This free wallchart from Nature Reviews Cancer and Nature Reviews Immunology provides a detailed overview of cancer-immune pathways, combination immunotherapies, and more.
Get Your Free Copy >- Accelerating T Cell Therapy ResearchObtaining high yields of viable engineered T cells for cell therapy research and immunotherapy development can be challenging. Lengthy and inefficient processes for cell isolation, cell culture, and gene transfer can cause delays and prevent scientists from reaching their goals. Watch as Drs. Sneha Balani and Angela Zhang discuss best practices and innovative technologies for T cell therapy research.
- Lost in Translation - Moving Your Research to Clinical TrialsThis webinar describes steps and considerations involved in translating research to the clinic.
- Transform Intracellular Delivery Using the CellPore™ Transfection SystemIntracellular delivery of molecules is a key step in biological research, but traditional transfection methods are often limited in their ability to efficiently deliver macromolecules across diverse cell types without altering cell phenotype and function. <br><br>Watch this on-demand webinar—originally presented as a workshop at AAI 2025—to learn how the CellPore™ Transfection System addresses these limitations by using mechanoporation to create transient membrane pores, enabling direct cytosolic delivery with high efficiency and cell viability.
- T Cell Nomenclature: From Subsets to ModulesA modular framework for classifying T cells by lineage, function, migration, differentiation, and antigen context.
- "Therapeutic T Cell Engineering" Featuring Drs. Carl June and Philipp RommelOn this episode of the Immunology Podcast, Drs. Carl June and Philipp Rommel discuss their research in lymphocyte biology, with a major translational focus on ex vivo T cell engineering for cancer and HIV cell-based therapies.
- Production of Chimeric Antigen Receptor T CellsThis free Nature Protocols Wallchart summarizes the processes involved in producing CAR T cells for therapy.
