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T Cell Therapy

Adoptive T cell therapy has brought excitement to immuno-oncology research and hope to cancer patients who are out of treatment options. The most popular form of T cell for therapy are chimeric antigen receptor (CAR) T cells. These cells are engineered to express a synthetic transmembrane receptors containing the variable domain of an antibody to redirect their specificity to recognize and eliminate cancer cells upon infusion in patients.

Below is a collection of scientific resources for your T cell therapy research.

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  1. Transform Intracellular Delivery Using the CellPore™ Transfection System
    Transform Intracellular Delivery Using the CellPoreâ„¢ Transfection System
    Intracellular delivery of molecules is a key step in biological research, but traditional transfection methods are often limited in their ability to efficiently deliver macromolecules across diverse cell types without altering cell phenotype and function. <br><br>Watch this on-demand webinar—originally presented as a workshop at AAI 2025—to learn how the CellPore™ Transfection System addresses these limitations by using mechanoporation to create transient membrane pores, enabling direct cytosolic delivery with high efficiency and cell viability.
  2. T Cell Nomenclature: From Subsets to Modules
    T Cell Nomenclature: From Subsets to Modules
    A modular framework for classifying T cells by lineage, function, migration, differentiation, and antigen context.
  3. "Therapeutic T Cell Engineering" Featuring Drs. Carl June and Philipp Rommel
    "Therapeutic T Cell Engineering" Featuring Drs. Carl June and Philipp Rommel
    On this episode of the Immunology Podcast, Drs. Carl June and Philipp Rommel discuss their research in lymphocyte biology, with a major translational focus on ex vivo T cell engineering for cancer and HIV cell-based therapies.
  4. Key Regulatory Considerations for Moving Your Cell Therapy Research to the Clinic
    Key Regulatory Considerations for Moving Your Cell Therapy Research to the Clinic
  5. Production of Chimeric Antigen Receptor T cells
    Production of Chimeric Antigen Receptor T Cells
    This free Nature Protocols Wallchart summarizes the processes involved in producing CAR T cells for therapy.
  6. Workflow Solutions for Human T Cell Isolation and Expansion
    Workflow Solutions for Human T Cell Isolation and Expansion
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  7. Rapid Expansion of Functional Human T Cells Using a Novel Serum-Free and Xeno-Free Culture Medium
    Rapid Expansion of Functional Human T Cells Using a Novel Serum-Free and Xeno-Free Culture Medium
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  8. Stroma-Free, Serum-Free Expansion and Differentiation of Hematopoietic Stem and Progenitor Cells to the T Cell Lineage
    Stroma-Free, Serum-Free Expansion and Differentiation of Hematopoietic Stem and Progenitor Cells to the T Cell Lineage
  9. Raw Material Qualification
    Ancillary Material Qualification
  10. Non-Viral CRISPR Knock-In Anti-B7-H3 CAR-T Cells Are Amenable for Treatment of Subtypes of Small Cell Lung Cancer
    Non-Viral CRISPR Knock-In Anti-B7-H3 CAR-T Cells Are Amenable for Treatment of Subtypes of Small Cell Lung Cancer
    In this webinar, Scientist Vimal Keerthi discusses his work on identifying CD276 (B7-H3) overexpression in primary human SCLC and developing a non-viral CRISPR-Cas9 knock-in (CKI) based platform against B7-H3 to manufacture CAR T cells for the treatment of SCLC. He demonstrates the feasibility of this CAR T manufacturing platform and how this provides a blueprint for immediate clinical translation, overcoming the bottleneck of viral vector production.<br><br>This webinar is part of the “Translational T Cell Talks: Scaling for the Future†event hosted in collaboration with Scientist.com on June 11, 2024. <a href="/translational-t-cell-talks-2024">View the rest of the talks and read the Q&A transcripts.</a>
  11. Genome Editing of Human Primary T Cells
    Genome Editing of Human Primary T Cells Using CRISPR-Cas9
  12. Roundtable: Improving Collaboration Between Industry and Academia in the Field of CAR T Cell Therapy
    Roundtable: Improving Collaboration Between Industry and Academia in the Field of CAR T Cell Therapy
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