Product Information
Items 2449 to 2460 of 13914 total
- Safety Data Sheet
Catalog #: Product Name: 60132 Anti-Rhesus Red Blood Cell Antibody, Clone T3G6 Catalog #: 60132 Product Name: Anti-Rhesus Red Blood Cell Antibody, Clone T3G6 - Product Information Sheet
Catalog #: Lot #: Language: Product Name: Catalog #:100-1422Lot #:AllLanguage:EnglishProduct Name:SARS-CoV-2 (Spike Protein) Omicron XBB.1.5.X Peptide PoolCatalog #: 100-1422 Lot #: All Language: English Product Name: SARS-CoV-2 (Spike Protein) Omicron XBB.1.5.X Peptide Pool - Reference(Nov 2024) Nature Communications 15
High incidence and geographic distribution of cleft palate in Finland are associated with the IRF6 gene
In Finland, the frequency of isolated cleft palate (CP) is higher than that of isolated cleft lip with or without cleft palate (CL/P). This trend contrasts to that in other European countries but its genetic underpinnings are unknown. We conducted a genome-wide association study in the Finnish population and identified rs570516915, a single nucleotide polymorphism highly enriched in Finns, as strongly associated with CP (P?=?5.25 × 10?34, OR?=?8.65, 95% CI 6.11–12.25), but not with CL/P (P?=?7.2 × 10?5), with genome-wide significance. The risk allele frequency of rs570516915 parallels the regional variation of CP prevalence in Finland, and the association was replicated in independent cohorts of CP cases from Finland (P?=?8.82 × 10?28) and Estonia (P?=?1.25 × 10?5). The risk allele of rs570516915 alters a conserved binding site for the transcription factor IRF6 within an enhancer (MCS-9.7) upstream of the IRF6 gene and diminishes the enhancer activity. Oral epithelial cells derived from CRISPR-Cas9 edited induced pluripotent stem cells demonstrate that the CP-associated allele of rs570516915 concomitantly decreases the binding of IRF6 and the expression level of IRF6, suggesting impaired IRF6 autoregulation as a molecular mechanism underlying the risk for CP. Here, the authors perform a genome-wide study and identify a genetic variant enriched in the Finnish population that is strongly associated with isolated cleft palate. This finding suggests a genetic basis for the high prevalence of cleft palate in Finland.Catalog #: Product Name: 85850 ³¾°Õ±ð³§¸éâ„¢1 Catalog #: 85850 Product Name: ³¾°Õ±ð³§¸éâ„¢1 Product Information SheetCatalog #: Lot #: Language: Product Name: Catalog #:100-1421Lot #:AllLanguage:EnglishProduct Name:SARS-CoV-2 (Spike Protein) Omicron BA.4/BA.5 Peptide PoolCatalog #: 100-1421 Lot #: All Language: English Product Name: SARS-CoV-2 (Spike Protein) Omicron BA.4/BA.5 Peptide Pool Reference(Jan 2025) Scientific Reports 15 Suppl 4Dysregulation of REST and its target genes impacts the fate of neural progenitor cells in down syndrome
Increasing shreds of evidence suggest that neurogenic-to-gliogenic shift may be critical to the abnormal neurodevelopment observed in individuals with Down syndrome (DS). REST, the Repressor Element-1 Silencing Transcription factor, regulates the differentiation and development of neural cells. Downregulation of REST may lead to defects in post-differentiation neuronal morphology in the brain of the DS fetal. This study aims to elucidate the role of REST in DS-derived NPCs using bioinformatics analyses and laboratory validations. We identified and validated vital REST-targeted DEGs: CD44, TGFB1, FN1, ITGB1, and COL1A1. Interestingly, these genes are involved in neurogenesis and gliogenesis in DS-derived NPCs. Furthermore, we identified nuclear REST loss and the neuroblast marker, DCX, was downregulated in DS human trisomic induced pluripotent stem cells (hiPSCs)-derived NPCs, whereas the glioblast marker, NFIA, was upregulated. Our findings indicate that the loss of REST is critical in the neurogenic-to-gliogenic shift observed in DS-derived NPCs. REST and its target genes may collectively regulate the NPC phenotype.Supplementary InformationThe online version contains supplementary material available at 10.1038/s41598-025-87314-y.Catalog #: Product Name: 100-0276 mTeSRâ„¢ Plus Catalog #: 100-0276 Product Name: mTeSRâ„¢ Plus Safety Data SheetCatalog #: Product Name: 60060BT Anti-Mouse SSEA-1 (CD15) Antibody, Clone MC-480, Biotin Catalog #: 60060BT Product Name: Anti-Mouse SSEA-1 (CD15) Antibody, Clone MC-480, Biotin Safety Data SheetCatalog #: Product Name: 60134BT Anti-Human CD24 Antibody, Clone 32D12, Biotin Catalog #: 60134BT Product Name: Anti-Human CD24 Antibody, Clone 32D12, Biotin Product Information SheetCatalog #: Lot #: Language: Product Name: Catalog #:100-1420Lot #:AllLanguage:EnglishProduct Name:SARS-CoV-2 (Spike Protein) Omicron/B.1.1.529 Peptide PoolCatalog #: 100-1420 Lot #: All Language: English Product Name: SARS-CoV-2 (Spike Protein) Omicron/B.1.1.529 Peptide Pool Reference(May 2024) Nature Communications 15Fluorescent fatty acid conjugates for live cell imaging of peroxisomes
Peroxisomes are eukaryotic organelles that are essential for multiple metabolic pathways, including fatty acid oxidation, degradation of amino acids, and biosynthesis of ether lipids. Consequently, peroxisome dysfunction leads to pediatric-onset neurodegenerative conditions, including Peroxisome Biogenesis Disorders (PBD). Due to the dynamic, tissue-specific, and context-dependent nature of their biogenesis and function, live cell imaging of peroxisomes is essential for studying peroxisome regulation, as well as for the diagnosis of PBD-linked abnormalities. However, the peroxisomal imaging toolkit is lacking in many respects, with no reporters for substrate import, nor cell-permeable probes that could stain dysfunctional peroxisomes. Here we report that the BODIPY-C12 fluorescent fatty acid probe stains functional and dysfunctional peroxisomes in live mammalian cells. We then go on to improve BODIPY-C12, generating peroxisome-specific reagents, PeroxiSPY650 and PeroxiSPY555. These probes combine high peroxisome specificity, bright fluorescence in the red and far-red spectrum, and fast non-cytotoxic staining, making them ideal tools for live cell, whole organism, or tissue imaging of peroxisomes. Finally, we demonstrate that PeroxiSPY enables diagnosis of peroxisome abnormalities in the PBD CRISPR/Cas9 cell models and patient-derived cell lines. The array of tools to image peroxisome regulation is still limited. Here, the authors develop improved fatty acid-based probes with high peroxisome specificity and bright fluorescence in the red/far-red spectrum, which makes them ideal to study peroxisomes in live cells and whole organisms.Catalog #: Product Name: 100-0276 mTeSRâ„¢ Plus Catalog #: 100-0276 Product Name: mTeSRâ„¢ Plus Safety Data SheetCatalog #: Product Name: 60004BT Anti-Human CD14 Antibody, Clone M5E2, Biotin Catalog #: 60004BT Product Name: Anti-Human CD14 Antibody, Clone M5E2, Biotin Product Information SheetCatalog #: Lot #: Language: Product Name: Catalog #:100-1383Lot #:AllLanguage:EnglishProduct Name:SARS-CoV-2 (Spike Protein) Omicron/B.1.1.529 WT Reference Peptide PoolCatalog #: 100-1383 Lot #: All Language: English Product Name: SARS-CoV-2 (Spike Protein) Omicron/B.1.1.529 WT Reference Peptide Pool Reference(Jun 2025) Experimental & Molecular Medicine 57 6Changes in mitochondrial thymidine metabolism and mtDNA copy number during induced pluripotency
Somatic cell reprogramming into human induced pluripotent stem cells entails significant intracellular changes, including modifications in mitochondrial metabolism and a decrease in mitochondrial DNA copy number. However, the mechanisms underlying this decrease in mitochondrial DNA copy number during reprogramming remain unclear. Here we aimed to elucidate these underlying mechanisms. Through a meta-analysis of several RNA sequencing datasets, we identified genes responsible for the decrease in mitochondrial DNA. We investigated the functions of these identified genes and assessed their regulatory mechanisms. In particular, the expression of the thymidine kinase 2 gene (TK2), located in the mitochondria and required for mitochondrial DNA synthesis, is decreased in human pluripotent stem cells as compared with its expression in somatic cells. TK2 was significantly downregulated during reprogramming and markedly upregulated during differentiation. Collectively, this decrease in TK2 levels induces a decrease in mitochondrial DNA copy number and contributes to shaping the metabolic characteristics of human pluripotent stem cells. However, contrary to our expectations, treatment with a TK2 inhibitor impaired somatic cell reprogramming. These results suggest that decreased TK2 expression may result from metabolic conversion during somatic cell reprogramming. Mitochondrial DNA loss linked to stem cell reprogrammingInduced pluripotent stem (iPS) cells are special cells created by reprogramming regular body cells. Researchers explored how these cells change their energy production methods during reprogramming. The study focused on a protein called thymidine kinase 2 (TK2), which is important for maintaining mitochondrial DNA (mtDNA). Mitochondria are the cell’s powerhouses, and their DNA is crucial for energy production. Researchers used human cell lines to study how TK2 affects mtDNA during reprogramming. They found that, as cells become iPS cells, TK2 levels drop, leading to reduced mtDNA and a shift in energy production from oxidative phosphorylation to glycolysis. Results suggest that reducing TK2 and mtDNA is key for cells to gain pluripotency. This shift helps support the rapid growth and development of iPS cells. Understanding this process could improve stem cell therapies and regenerative medicine in the future.This summary was initially drafted using artificial intelligence, then revised and fact-checked by the author.Catalog #: Product Name: 05914 TeSRâ„¢-E7â„¢ Medium for Reprogramming (2-Component) 05990 °Õ±ð³§¸éâ„¢-·¡8â„¢ Catalog #: 05914 Product Name: TeSRâ„¢-E7â„¢ Medium for Reprogramming (2-Component) Catalog #: 05990 Product Name: °Õ±ð³§¸éâ„¢-·¡8â„¢ Items 2449 to 2460 of 13914 total
Shop ByFilter Results- Resource Type
-
- Product Information Sheet 2907 items
- Reference 7892 items
- Safety Data Sheet 3052 items
- Technical Manual 63 items
- Product Type
-
- 35 items
- Cell Culture Media and Supplements 27 items
- Cell Engineering and Molecular Tools 3 items
- Cell Isolation Products 5 items
- Instruments and Software 4 items
- Tissue and Cell Culture Dissociation Reagents 2 items
- Training and Education 1 item
- Area of Interest
-
- 29 items
- Angiogenic Cell Research 49 items
- Antibody Development 1 item
- Cancer 601 items
- Cell Line Development 137 items
- Cell Therapy Development 1 item
- Chimerism 5 items
- Cord Blood Banking 25 items
- Disease Modeling 4 items
- Drug Discovery and Toxicity Testing 182 items
- Endothelial Cell Biology 2 items
- Epithelial Cell Biology 158 items
- HIV 52 items
- HLA 8 items
- Hybridoma Generation 1 item
- Immunology 743 items
- Infectious Diseases 4 items
- Neuroscience 491 items
- Organoids 1 item
- Respiratory Research 1 item
- Stem Cell Biology 2493 items
- Transplantation Research 54 items
- Brand
-
- 0 20 items
- ALDECOUNT 7 items
- ALDEFLUOR 216 items
- AggreWell 55 items
- ArciTect 1 item
- BrainPhys 45 items
- CellPore 1 item
- ClonaCell 84 items
- CryoStor 65 items
- ES-Cult 77 items
- EasyPick 1 item
- EasySep 752 items
- EpiCult 12 items
- HepatiCult 1 item
- ImmunoCult 7 items
- IntestiCult 142 items
- Lymphoprep 9 items
- MammoCult 45 items
- MegaCult 34 items
- MesenCult 133 items
- MethoCult 444 items
- MyeloCult 64 items
- MyoCult 2 items
- NeuroCult 353 items
- NeuroFluor 1 item
- PancreaCult 3 items
- PneumaCult 78 items
- RSeT 7 items
- ReLeSR 1 item
- RoboSep 23 items
- RosetteSep 253 items
- STEMdiff 54 items
- STEMvision 3 items
- SepMate 29 items
- StemSpan 219 items
- TeSR 1456 items
- ThawSTAR 1 item
- mFreSR 3 items
- Cell and Tissue Source
-
- 24 items
- Cell Line
-
- 24 items
- Cell Type
-
- 27 items
- Airway Cells 41 items
- B Cells 134 items
- Brain Tumor Stem Cells 81 items
- Cancer Cells and Cell Lines 116 items
- Cardiomyocytes, PSC-Derived 8 items
- Dendritic Cells 59 items
- Dermal Cells 1 item
- Endoderm, PSC-Derived 1 item
- Endothelial Cells 1 item
- Endothelial Cells, PSC-Derived 1 item
- Epithelial Cells 49 items
- Granulocytes and Subsets 61 items
- Hematopoietic Stem and Progenitor Cells 777 items
- Hepatic Cells 2 items
- Hybridomas 75 items
- Innate Lymphoid Cells 3 items
- Intestinal Cells 13 items
- Kidney Cells 1 item
- Leukemia/Lymphoma Cells 8 items
- Leukopaks 1 item
- Mammary Cells 68 items
- Mesenchymal Stem and Progenitor Cells 132 items
- Monocytes 105 items
- Mononuclear Cells 33 items
- Myeloid Cells 99 items
- NK Cells 80 items
- Neural Cells, PSC-Derived 17 items
- Neural Stem and Progenitor Cells 381 items
- Neurons 135 items
- Plasma 3 items
- Pluripotent Stem Cells 1689 items
- Prostate Cells 7 items
- Renal Cells 2 items
- T Cells 179 items
- T Cells, CD4+ 85 items
- T Cells, CD8+ 49 items
- T Cells, Regulatory 18 items
- Species
-
- 41 items
Loading...Copyright © 2025 º£½ÇÆÆ½â°æ. All rights reserved.