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- Reference(Feb 2025) Nature Communications 16
WNT11 Promotes immune evasion and resistance to Anti-PD-1 therapy in liver metastasis
Liver metastasis (LM) poses a significant challenge in cancer treatment, with limited available therapeutic options and poor prognosis. Understanding the dynamics of tumor microenvironment (TME) and immune interactions is crucial for developing effective treatments. We find that WNT11 promoted CD8+ T-cell exclusion and suppression, which was correlated with poor prognosis in LM. Mechanistically, WNT11-overexpressing tumor cells directly reduce CD8+ T-cell recruitment and activity by decreasing CXCL10 and CCL4 expression through CAMKII-mediated β-catenin/AFF3 downregulation. WNT11-overexpressing tumor cells promote immunosuppressive macrophage polarization by inducing IL17D expression via the CAMKII/NF-κB pathway, which result in CD8+ T-cell suppression. Moreover, CAMKII inhibition increases the efficacy of anti-PD-1 therapy in mouse model of LM. Serum expression of WNT11 is identified as a potential minimally invasive biomarker in the management of colorectal cancer-LM with immunotherapy. Our findings highlight WNT11/CAMKII axis as a critical regulator of the TME and a promising target for immunotherapy in patients with LM. Activation of the WNT/β-catenin signaling pathway has been associated with immune evasion in several cancer types. Here the authors show that expression of WNT11, a member of the non-canonical WNT signaling pathway, is associated with CD8 + T cell exclusion and resistance to immune checkpoint inhibitors in liver metastasis.Catalog #: Product Name: 18945 EasySep™ Mouse CD45 Positive Selection Kit 100-0659 EasySep™ Mouse F4/80 Positive Selection Kit Catalog #: 18945 Product Name: EasySep™ Mouse CD45 Positive Selection Kit Catalog #: 100-0659 Product Name: EasySep™ Mouse F4/80 Positive Selection Kit Reference(Feb 2025) Nature Communications 16Metabolic deficiencies underlie reduced plasmacytoid dendritic cell IFN-I production following viral infection
Type I Interferons (IFN-I) are central to host protection against viral infections, with plasmacytoid dendritic cells (pDC) being the most significant source, yet pDCs lose their IFN-I production capacity following an initial burst of IFN-I, resulting in susceptibility to secondary infections. The underlying mechanisms of these dynamics are not well understood. Here we find that viral infection reduces the capacity of pDCs to engage both oxidative and glycolytic metabolism. Mechanistically, we identify lactate dehydrogenase B (LDHB) as a positive regulator of pDC IFN-I production in mice and humans; meanwhile, LDHB deficiency is associated with suppressed IFN-I production, pDC metabolic capacity, and viral control following infection. In addition, preservation of LDHB expression is sufficient to partially retain the function of otherwise exhausted pDCs, both in vitro and in vivo. Furthermore, restoring LDHB in vivo in pDCs from infected mice increases IFNAR-dependent, infection-associated pathology. Our work thus identifies a mechanism for balancing immunity and pathology during viral infections, while also providing insight into the highly preserved infection-driven pDC inhibition. Plasmacytoid dendritic cells (pDC) are the major IFN-I-producing cells, but this production returns to baseline soon after viral infection. Here the authors show that this decrease in IFN-I production and related pDC functions may be attributed to suppressed oxidative and glycolytic metabolism of pDCs, with lactate dehydrogenase B identified as a regulator.Catalog #: Product Name: 19062 EasySepâ„¢ Human Plasmacytoid DC Enrichment Kit 19860 EasySepâ„¢ Mouse Streptavidin RapidSpheresâ„¢ Isolation Kit Catalog #: 19062 Product Name: EasySepâ„¢ Human Plasmacytoid DC Enrichment Kit Catalog #: 19860 Product Name: EasySepâ„¢ Mouse Streptavidin RapidSpheresâ„¢ Isolation Kit Reference(Feb 2025) Nature Communications 16Single cell suppression profiling of human regulatory T cells
Regulatory T cells (Treg) play an important role in regulating immune homeostasis in health and disease. Traditionally their suppressive function has been assayed by mixing purified cell populations, which does not provide an accurate picture of a physiologically relevant response. To overcome this limitation, we here develop ‘single cell suppression profiling of human Tregs’ (scSPOT). scSPOT uses a 52-marker CyTOF panel, a cell division detection algorithm, and a whole PBMC system to assess the effect of Tregs on all other cell types simultaneously. In this head-to-head comparison, we find Tregs having the clearest suppressive effects on effector memory CD8 T cells through partial division arrest, cell cycle inhibition, and effector molecule downregulation. Additionally, scSPOT identifies a Treg phenotypic split previously observed in viral infection and propose modes of action by the FDA-approved drugs Ipilimumab and Tazemetostat. scSPOT is thus scalable, robust, widely applicable, and may be used to better understand Treg immunobiology and screen for therapeutic compounds. Traditional regulatory T cell (Tregs) assays utilize mixture of purified cell population. Here the authors develop a ‘single cell suppression profiling of human Tregs’ (scSPOT) with 52-marker CyTOF panel, a cell division detection algorithm, and a whole PBMC system to assess Treg suppressive function on all cell types simultaneously.Catalog #: Product Name: 17752 EasySep™ Release Human CD4 Positive Selection Kit 18000 EasySep™ Magnet Catalog #: 17752 Product Name: EasySep™ Release Human CD4 Positive Selection Kit Catalog #: 18000 Product Name: EasySep™ Magnet Reference(Jan 2025) Nucleic Acids Research 53 3Telomemore enables single-cell analysis of cell cycle and chromatin condensation
AbstractSingle-cell RNA-seq methods can be used to delineate cell types and states at unprecedented resolution but do little to explain why certain genes are expressed. Single-cell ATAC-seq and multiome (ATACÂ +Â RNA) have emerged to give a complementary view of the cell state. It is however unclear what additional information can be extracted from ATAC-seq data besides transcription factor binding sites. Here, we show that ATAC-seq telomere-like reads counter-inituively cannot be used to infer telomere length, as they mostly originate from the subtelomere, but can be used as a biomarker for chromatin condensation. Using long-read sequencing, we further show that modern hyperactive Tn5 does not duplicate 9 bp of its target sequence, contrary to common belief. We provide a new tool, Telomemore, which can quantify nonaligning subtelomeric reads. By analyzing several public datasets and generating new multiome fibroblast and B-cell atlases, we show how this new readout can aid single-cell data interpretation. We show how drivers of condensation processes can be inferred, and how it complements common RNA-seq-based cell cycle inference, which fails for monocytes. Telomemore-based analysis of the condensation state is thus a valuable complement to the single-cell analysis toolbox. Graphical Abstract Graphical AbstractCatalog #: Product Name: 17954 EasySepâ„¢ Human B Cell Isolation Kit Catalog #: 17954 Product Name: EasySepâ„¢ Human B Cell Isolation Kit Reference(Jan 2025) Biomarker Research 13 3ROR1 CAR-T cells and ferroptosis inducers orchestrate tumor ferroptosis via PC-PUFA2
BackgroundLung cancer, particularly non-small cell lung cancer (NSCLC), has high recurrence rates and remains a leading cause of cancer-related death, despite recent advances in its treatment. Emerging therapies, such as chimeric antigen receptor (CAR)-T cell therapy, have shown promise but face significant challenges in targeting solid tumors. This study investigated the potential of combining receptor tyrosine kinase-like orphan receptor 1 (ROR1)-targeting CAR-T cells with ferroptosis inducers to promote ferroptosis of tumor cells and enhance anti-tumor efficacy.MethodsRNA-seq data and immunofluorescence analysis of relapsed NSCLC patient samples were used to explore ROR1 expression. In addition, ROR1-targeting CAR-T cells were developed to assess cytotoxic activity against ROR1+ tumor cells, and the effect of cytokine stimulation on their efficacy was evaluated. Lipidomics, immunofluorescent histochemistry, and western blotting were used to explore the observed effects. Ferroptosis indicators, including levels of reactive oxygen species, were used to detect the combined effect of CAR-T cells and ferroptosis-inducing drugs. Finally, tumor-bearing mice were used to validate the in vivo efficacy of the combination therapy strategy.ResultsTumor cells treated with ferroptosis inducers showed increased sensitivity to Interferon gamma (IFN-γ) secreted by ROR1 CAR-T cells. Furthermore, ROR1 CAR-T cells enhanced the production of phosphatidylcholine with diacyl-polyunsaturated fatty acid tails (PC-PUFA2) by working in tandem with IFN-γ. This enhancement promoted the expression of acyl-CoA synthetase long chain family member 4 (ACSL4), which in turn strengthened the overall anti-tumor response.ConclusionsCombining ROR1 CAR-T cells with ferroptosis inducers enhanced anti-tumor efficacy in NSCLC by promoting ferroptosis through increased lipid peroxidation.Supplementary InformationThe online version contains supplementary material available at 10.1186/s40364-025-00730-0.Catalog #: Product Name: 17951 EasySep™ Human T Cell Isolation Kit Catalog #: 17951 Product Name: EasySep™ Human T Cell Isolation Kit Reference(Jan 2025) Experimental Hematology & Oncology 14 8Construction and characterization of chimeric FcγR T cells for universal T cell therapy
BackgroundSeveral approaches are being explored for engineering off-the-shelf chimeric antigen receptor (CAR) T cells. In this study, we engineered chimeric Fcγ receptor (FcγR) T cells and tested their potential as a versatile platform for universal T cell therapy.MethodsChimeric FcγR (CFR) constructs were generated using three distinct forms of FcγR, namely CD16A, CD32A, and CD64. The functionality of CFR T cells was evaluated through degranulation assays, specific target lysis experiments, in vitro cytokine production analysis, and assessment of tumor xenograft destruction specificity in mouse models using different monoclonal antibodies (MoAbs).ResultsThree types of CFR T cells were engineered, 16s3, 32-8a, 64-8a CFR T cells. In the presence of rituximab (RTX), cytotoxicity of all three types of CFR T cells against CD20+ Raji-wt, K562-CD20+, and primary tumor cells was significantly higher than that of the mock T cells (P < 0.001). When herceptin was used, all three types of CFR T cells exhibited significant cytotoxicity against HER2+ cell lines of SK-BR-3, SK-OV-3, and HCC1954 (P < 0.001). The cytotoxicity of 64-8a CFR T cells was significantly inhibited by free human IgG at a physiological dose (P < 0.001), which was not observed in 16s3, 32-8a CFR T cells. Compared to 32-8a CFR T cells, 16s3 CFR T cells exhibited more prolonged cytotoxicity than 32-8a CFR T cells (P < 0.01). In in vivo assays using xenograft models, 16s3 CFR T cells significantly prolonged the survival of mice xenografted with Raji-wt cells in the presence of RTX (P < 0.001), and effectively reduced tumor burden in mice xenografted with SK-OV-3 cells in the presence of herceptin (P < 0.05). No significant non-specific cytotoxicity of CFR T cells was found in vivo.ConclusionThe anti-tumor effects of the CFR T cells in vitro and in xenograft mouse models are mediated by specific MoAbs such as RTX and herceptin. The CFR T cells therefore have the features of universal T cells with specificity directed by MoAbs. 16s3 CFR T cells are chosen for clinical trials.Supplementary InformationThe online version contains supplementary material available at 10.1186/s40164-025-00595-x.Catalog #: Product Name: 17954 EasySep™ Human B Cell Isolation Kit Catalog #: 17954 Product Name: EasySep™ Human B Cell Isolation Kit Reference(Jan 2025) Nature Communications 16A cell atlas of the human fallopian tube throughout the menstrual cycle and menopause
The fallopian tube undergoes extensive molecular changes during the menstrual cycle and menopause. We use single-cell RNA and ATAC sequencing to construct a comprehensive cell atlas of healthy human fallopian tubes during the menstrual cycle and menopause. Our scRNA-seq comparison of 85,107 pre- and 46,111 post-menopausal fallopian tube cells reveals substantial shifts in cell type frequencies, gene expression, transcription factor activity, and cell-to-cell communications during menopause and menstrual cycle. Menstrual cycle dependent hormonal changes regulate distinct molecular states in fallopian tube secretory epithelial cells. Postmenopausal fallopian tubes show high chromatin accessibility in transcription factors associated with aging such as Jun, Fos, and BACH1/2, while hormone receptors were generally downregulated, a small proportion of secretory epithelial cells had high expression of ESR2, IGF1R, and LEPR. While a pre-menopausal secretory epithelial gene cluster is enriched in the immunoreactive molecular subtype, a subset of genes expressed in post-menopausal secretory epithelial cells show enrichment in the mesenchymal molecular type of high-grade serous ovarian cancer. The fallopian tube undergoes extensive cellular and molecular changes during the menstrual cycle and aging. Here, Weigert et al. present a single-cell atlas of the normal human fallopian tube revealing the transition of secretory epithelial cells throughout the menstrual cycle and menopause.Catalog #: Product Name: 18170 EasySep™ RBC Depletion Reagent Catalog #: 18170 Product Name: EasySep™ RBC Depletion Reagent Reference(Dec 2024) Stem Cell Research & Therapy 15 16Enhanced fetal hemoglobin production via dual-beneficial mutation editing of the HBG promoter in hematopoietic stem and progenitor cells for β-hemoglobinopathies
BackgroundSickle cell disease (SCD) and β-thalassemia patients with elevated gamma globin (HBG1/G2) levels exhibit mild or no symptoms. To recapitulate this natural phenomenon, the most coveted gene therapy approach is to edit the regulatory sequences of HBG1/G2 to reactivate them. By editing more than one regulatory sequence in the HBG promoter, the production of fetal hemoglobin (HbF) can be significantly increased. However, achieving this goal requires precise nucleotide conversions in hematopoietic stem and progenitor cells (HSPCs) at therapeutic efficiency, which remains a challenge.MethodsWe employed Cas9 RNP-ssODN-mediated homology-directed repair (HDR) gene editing to mimic two naturally occurring HBG promoter point mutations; -175T > C, associated with high HbF levels, and −158 C > T, a common polymorphism in the Indian population that induces HbF under erythropoietic stress, in HSPCs.ResultsAsymmetric, nontarget ssODN induced high rates of complete HDR conversions, with at least 15% of HSPCs exhibiting both the −175T > C and −158 C > T mutations. Optimized conditions and treatment with the small molecule AZD-7648 increased this rate, with up to 57% of long-term engrafting human HSPCs in NBSGW mice containing at least one beneficial mutation. Functionally, in vivo erythroblasts exhibited high levels of HbF, which was sufficient to reverse the cellular phenotype of β-thalassemia. Further support through bone marrow MSC co-culture boosted complete HDR conversion rates to exceed 80%, with minimal InDels, improved cell viability, and induced fetal hemoglobin levels similar to those of Cas9 RNP-mediated indels at BCL11A enhancer and HBG promoter.ConclusionsCas9 RNP-ssODN-based nucleotide conversion at the HBG promoter offers a promising gene therapy approach to ameliorate the phenotypes of β-thalassemia and SCD. The developed approach can simplify and broaden applications that require the cointroduction of multiple nucleotide modifications in HSPCs.Supplementary InformationThe online version contains supplementary material available at 10.1186/s13287-024-04117-0.Catalog #: Product Name: 09600 StemSpanâ„¢ SFEM 09605 StemSpanâ„¢ SFEM II 17856 EasySepâ„¢ Human CD34 Positive Selection Kit II Catalog #: 09600 Product Name: StemSpanâ„¢ SFEM Catalog #: 09605 Product Name: StemSpanâ„¢ SFEM II Catalog #: 17856 Product Name: EasySepâ„¢ Human CD34 Positive Selection Kit II Reference(Dec 2024) Clinical and Translational Medicine 14 12LRHâ€1/NR5A2 targets mitochondrial dynamics to reprogram type 1 diabetes macrophages and dendritic cells into an immune tolerance phenotype
AbstractBackgroundThe complex aetiology of type 1 diabetes (T1D), characterised by a detrimental crossâ€talk between the immune system and insulinâ€producing beta cells, has hindered the development of effective diseaseâ€modifying therapies. The discovery that the pharmacological activation of LRHâ€1/NR5A2 can reverse hyperglycaemia in mouse models of T1D by attenuating the autoimmune attack coupled to beta cell survival/regeneration prompted us to investigate whether immune tolerisation could be translated to individuals with T1D by LRHâ€1/NR5A2 activation and improve islet survival.MethodsPeripheral blood mononuclear cells (PBMCs) were isolated from individuals with and without T1D and derived into various immune cells, including macrophages and dendritic cells. Cell subpopulations were then treated or not with BL001, a pharmacological agonist of LRHâ€1/NR5A2, and processed for: (1) Cell surface marker profiling, (2) cytokine secretome profiling, (3) autologous Tâ€cell proliferation, (4) RNAseq and (5) proteomic analysis. BL001â€target gene expression levels were confirmed by quantitative PCR. Mitochondrial function was evaluated through the measurement of oxygen consumption rate using a Seahorse XF analyser. Coâ€cultures of PBMCs and iPSCsâ€derived islet organoids were performed to assess the impact of BL001 on beta cell viability.ResultsLRHâ€1/NR5A2 activation induced a genetic and immunometabolic reprogramming of T1D immune cells, marked by reduced proâ€inflammatory markers and cytokine secretion, along with enhanced mitohormesis in proâ€inflammatory M1 macrophages and mitochondrial turnover in mature dendritic cells. These changes induced a shift from a proâ€inflammatory to an antiâ€inflammatory/tolerogenic state, resulting in the inhibition of CD4+ and CD8+ Tâ€cell proliferation. BL001 treatment also increased CD4+/CD25+/FoxP3+ regulatory Tâ€cells and Th2 cells within PBMCs while decreasing CD8+ Tâ€cell proliferation. Additionally, BL001 alleviated PBMCâ€induced apoptosis and maintained insulin expression in human iPSCâ€derived islet organoids.ConclusionThese findings demonstrate the potential of LRHâ€1/NR5A2 activation to modulate immune responses and support beta cell viability in T1D, suggesting a new therapeutic approach.Key Points LRHâ€1/NR5A2 activation in inflammatory cells of individuals with type 1 diabetes (T1D) reduces proâ€inflammatory cell surface markers and cytokine release.LRHâ€1/NR5A2 promotes a mitohormesisâ€induced immunoâ€resistant phenotype to proâ€inflammatory macrophages.Mature dendritic cells acquire a tolerogenic phenotype via LRHâ€1/NR5A2â€stimulated mitochondria turnover.LRHâ€1/NR5A2 agonistic activation expands a CD4+/CD25+/FoxP3+ Tâ€cell subpopulation.Pharmacological activation of LRHâ€1/NR5A2 improves the survival iPSCâ€isletsâ€like organoids coâ€cultured with PBMCs from individuals with T1D. LRHâ€1/NR5A2 activation in inflammatory cells of individuals with type 1 diabetes (T1D) reduces proâ€inflammatory cell surface markers and cytokine release.LRHâ€1/NR5A2 promotes a mitohormesisâ€induced immunoâ€resistant phenotype to proâ€inflammatory macrophages.Mature dendritic cells acquire a tolerogenic phenotype via LRHâ€1/NR5A2â€stimulated mitochondria turnover.LRHâ€1/NR5A2 agonistic activation expands a CD4+/CD25+/FoxP3+ Tâ€cell subpopulation.Pharmacological activation of LRHâ€1/NR5A2 improves the survival iPSCâ€isletsâ€like organoids coâ€cultured with PBMCs from individuals with T1D.Catalog #: Product Name: 17858 EasySepâ„¢ Human CD14 Positive Selection Kit II 17952 EasySepâ„¢ Human CD4+ T Cell Isolation Kit Catalog #: 17858 Product Name: EasySepâ„¢ Human CD14 Positive Selection Kit II Catalog #: 17952 Product Name: EasySepâ„¢ Human CD4+ T Cell Isolation Kit Reference(Dec 2024) Blood Cancer Journal 14 1Expanded tumor-associated polymorphonuclear myeloid-derived suppressor cells in Waldenstrom macroglobulinemia display immune suppressive activity
The role of the bone marrow (BM) microenvironment in regulating the antitumor immune response in Waldenstrom macroglobulinemia (WM) remains poorly understood. Here we transcriptionally and phenotypically profiled non-malignant (CD19- CD138-) BM cells from WM patients with a focus on myeloid derived suppressive cells (MDSCs) to provide a deeper understanding of their role in WM. We found that HLA-DRlowCD11b+CD33+ MDSCs were significantly increased in WM patients as compared to normal controls, with an expansion of predominantly polymorphonuclear (PMN)-MDSCs. Single-cell immunogenomic profiling of WM MDSCs identified an immune-suppressive gene signature with upregulated inflammatory pathways associated with interferon and tumor necrosis factor (TNF) signaling. Gene signatures associated with an inflammatory and immune suppressive environment were predominately expressed in PMN-MDSCs. In vitro, WM PMN-MDSCs demonstrated robust T-cell suppression and their viability and expansion was notably enhanced by granulocyte colony stimulating factor (G-CSF) and TNFα. Furthermore, BM malignant B-cells attracted PMN-MDSCs to a greater degree than monocytic MDSCs. Collectively, these data suggest that malignant WM B cells actively recruit PMN-MDSCs which promote an immunosuppressive BM microenvironment through a direct T cell inhibition, while release of G-CSF/TNFα in the microenvironment further promotes PMN-MDSC expansion and in turn immune suppression. Targeting PMN-MDSCs may therefore represent a potential therapeutic strategy in patients with WM.Catalog #: Product Name: 17882 EasySep™ HLA Chimerism Whole Blood CD66b Positive Selection Kit Catalog #: 17882 Product Name: EasySep™ HLA Chimerism Whole Blood CD66b Positive Selection Kit Reference(Dec 2024) International Journal of Molecular Sciences 25 23Single-Cell RNA Sequencing of PBMCs Identified Junction Plakoglobin (JUP) as Stratification Biomarker for Endometriosis
This study aimed to identify unique characteristics in the peripheral blood mononuclear cells (PBMCs) of endometriosis patients and develop a non-invasive early diagnostic tool. Using single-cell RNA sequencing (scRNA-seq), we constructed the first single-cell atlas of PBMCs from endometriosis patients based on 107,964 cells and 25,847 genes. Within CD16+ monocytes, we discovered JUP as a dysregulated gene. To assess its diagnostic potential, we measured peritoneal fluid (PF) and serum JUP levels in a large cohort of 199 patients including 20 women with ovarian cancer (OC). JUP was barely detectable in PF but was significantly elevated in the serum of patients with endometriosis and OC, with levels 1.33 and 2.34 times higher than controls, respectively. Additionally, JUP was found in conditioned culture media of CD14+/CD16+ monocytes aligning with our scRNA-seq data. Serum JUP levels correlated with endometriosis severity and endometrioma presence but were unaffected by dysmenorrhea, menstrual cycle, or adenomyosis. When combined with CA125 (cancer antigen 125) JUP enhanced the specificity of endometriosis diagnosis from 89.13% (CA125 measured alone) to 100%. While sensitivity remains a challenge at 19%, our results suggest that JUP’s potential to enhance diagnostic accuracy warrants additional investigation. Furthermore, employing serum JUP as a stratification marker unlocked the potential to identify additional endometriosis-related genes, offering novel insights into disease pathogenesis.Catalog #: Product Name: 19058 EasySep™ Human Monocyte Enrichment Kit without CD16 Depletion 18000 EasySep™ Magnet Catalog #: 19058 Product Name: EasySep™ Human Monocyte Enrichment Kit without CD16 Depletion Catalog #: 18000 Product Name: EasySep™ Magnet Reference(Nov 2024) Molecular Therapy. Methods & Clinical Development 32 4Generation and maintenance of kidney and kidney cancer organoids from patient-derived material for drug development and precision oncology
Despite significant advancements in targeted- and immunotherapies, millions of patients with cancer still succumb to the disease each year. In renal cell carcinoma, up to 25% of metastatic patients do not respond to first-line therapies. This reality underscores the urgent need for innovative or repurposed therapies to effectively treat these patients. Patient-derived organoids represent a promising model for evaluating treatment efficacy and toxicity, offering a potential breakthrough in personalized medicine. However, utilizing organoid models for drug screening presents several challenges. Our protocol aims to address these obstacles by outlining a practical approach to successfully isolate and cultivate patient-derived renal cell carcinoma and kidney organoids for treatment screening purposes. Graphical abstract Patient-derived organoids represent a promising model for evaluating treatment efficacy and toxicity, offering a potential breakthrough in personalized medicine. Nowak-Sliwinska and colleagues present a detailed protocol for obtaining kidney and kidney cancer organoids for drug development and precision oncology.Catalog #: Product Name: 17899 EasySepâ„¢ Dead Cell Removal (Annexin V) Kit Catalog #: 17899 Product Name: EasySepâ„¢ Dead Cell Removal (Annexin V) Kit Items 1381 to 1392 of 13914 total
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