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Neurological Disease Modeling

Due to the difficulty in obtaining human brain tissue for experimental studies, animal models have traditionally been popular tools for neurological disease modeling and therapeutic evaluation. In recent years, however, researchers have begun using induced pluripotent stem cells (iPSCs) to generate more representative models for studying human neurological disease. These iPSC-based models, including iPSC-derived neurons, glia, neural organoids, and co-cultures, hold tremendous potential for drug discovery applications and studying human neurological disease. Researchers can now generate patient-specific differentiated cell types, bridging the translational gap between studies using animal models and clinical research.

We’ve created these resources to help you with your research in neurological disease modeling and drug discovery, and to give you a taste of what others are doing in the field.

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  1. The Road to Functional Human Neuronal Circuits in Vitro
    The Road to Functional Human Neuronal Circuits in Vitro
    Active neurons are a vital part of a functioning brain and an essential component of in vitro neurological models. In this webinar, Dr. Cedric Bardy talks about why and how he invented BrainPhys™, a new neuronal basal medium that better supports neuronal function in vitro, described in C Bardy et al. Proc Natl Acad Sci USA, 2015. Dr. Bardy describes how BrainPhys™ increases the physiological relevance of primary and hPSC-derived neuronal cultures in vitro.
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