Cell Culture Scale-Up
When culturing stem cells, "scale-up" can take on various meanings depending on your goals. Whether you want to increase the quantity or yield of your chosen cell type(s), move from traditional two-dimensional (2D) culture systems to three-dimensional (3D) platforms, or transition to large-scale clinical manufacturing, º£½ÇÆƽâ°æ Technologies can support you with tools, expertise, and guidance tailored to every aspect of scale-up.
Browse the resources below for insights on scaling up human pluripotent stem cells (hPSCs), immune cells, hematopoietic stem and progenitor cells (HSPCs), and other specialized cell types. Topics include maintaining characteristics like pluripotency and differentiation potential, meeting compliance regulations, optimizing cultures to achieve high yields, and adopting systems to mimic in vivo conditions for disease modeling, drug discovery, and therapeutic development.
On-Demand Ancillary Materials Course
In this self-paced, virtual course, you will learn how ancillary materials influence the safety, consistency, and scalability of cell and gene therapy manufacturing. Understanding these impacts is essential to successfully scaling up production while maintaining product quality and regulatory compliance.
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“Laser-Based Cell Manipulation†Featuring Dr. Marinna MadridOn this episode of the Stem Cell Podcast, Dr. Marinna Madrid from Cellino discusses how lasers and image-guided machine learning can make iPSC-derived cell therapies viable at a large scale. -
Expansion of hPSCs in 3D Suspension Culture CourseLearn from our in-house PSC experts as they demonstrate how to expand and scale-up hPSCs in 3D suspension culture. -
How to Process a Leukopak for Downstream Cell IsolationHow to process a leukopak for isolating cells using manual or automated immunomagnetic and column-free EasySepâ„¢ cell isolation kits -
Quality by Design: Reagents and Support for hPSC-Derived Cell and Gene TherapiesEach year, more human pluripotent stem cell-derived (hPSC-derived) therapies move towards the clinic, and º£½ÇÆƽâ°æ is committed to supporting researchers from discovery to clinical application. In this Innovation Showcase from ISSCR 2021, Lynn Csontos will demonstrate how we build quality into our products, processes, and policies to support your project timing, product quality, and overall vision. Kimberly Snyder will then present data that shows how TeSRâ„¢-AOF, a novel animal origin-free (AOF) hPSC maintenance medium, can support optimized cell quality, improved performance and reproducibility across all cell lines. -
“Translating Stem Cell Discoveries†Featuring Dr. Ilyas SingeçOn this episode of the Stem Cell Podcast, Dr. Ilyas Singeç from National Center for Advancing Translational Sciences discusses standardizing stem cell differentiation, high-throughput cell culture, personalized medicine, and the potential for biomanufacturing in space. -
Serum-Free Expansion of CD34+ Cells with SFEM II and UM729Explore the use of StemSpanâ„¢ SFEM II medium, StemSpanâ„¢ CD34+ Expansion Supplement and small molecules UM171 or UM729 to enhance expansion of HSPCs
