Enhancing Genetic Stability in hPSC Cultures: Introducing ±ð°Õ±ð³§¸éâ„¢ for Single-Cell hPSC Maintenance
In this Innovation Showcase talk from ISSCR 2023, Dr. Adam Hirst, one of º£½ÇÆƽâ°æ’s Senior Scientists, introduces ±ð°Õ±ð³§¸éâ„¢, a novel hPSC maintenance medium developed specifically to maintain cell quality when passaging hPSCs as single cells.
Genetic instability in human pluripotent stem cell (hPSC) cultures remains a substantial concern for research and therapeutic development outcomes, especially when cells are exposed to stressful culture conditions such as long-term single-cell passaging. In this presentation, º£½ÇÆƽâ°æ Technologies’ Senior Scientist Adam Hirst introduces ±ð°Õ±ð³§¸éâ„¢, an hPSC maintenance medium specifically developed to preserve genetic stability and cell quality during routine single-cell passaging. The formulation is optimized to support hPSC expansion while reducing cellular stress and has been tested using large-scale, long-term genetic stability studies across multiple hPSC lines. When compared against other commercially available media, the data demonstrate that hPSCs cultured in ±ð°Õ±ð³§¸éâ„¢ display stable morphology, preserved pluripotency and trilineage differentiation, and higher genetic stability.
As a sponsor of, and participant in, ISSCR’s 2023 Annual Meeting, we share with you our Innovation Showcase presentation at #ISSCR2023. This presentation does not represent an endorsement from or support of the ISSCR.
Key topics covered in this webinar:
Long-term single-cell passaging places hPSCs under significant selective pressure, increasing the risk of recurrent genetic abnormalities that can affect research outcomes. By using ±ð°Õ±ð³§¸éâ„¢, a medium specifically designed for hPSCs maintained as single-cell cultures, researchers can preserve genetic stability to achieve more reliable, reproducible gene editing, clonal expansion, and downstream differentiation workflows.
As a sponsor of, and participant in, ISSCR’s 2023 Annual Meeting, we share with you our Innovation Showcase presentation at #ISSCR2023. This presentation does not represent an endorsement from or support of the ISSCR.
Key topics covered in this webinar:
- • Genetic instability as a challenge in hPSC culture
- • Increased popularity of single-cell passaging in hPSC workflows
- • Development and use of ±ð°Õ±ð³§¸éâ„¢ hPSC maintenance medium
- • Culture performance and quality characterization in ±ð°Õ±ð³§¸éâ„¢
- • Gene editing and cloning compatibility with ±ð°Õ±ð³§¸éâ„¢
- • Comparative, large-scale assessment of long-term genetic stability in single-cell hPSC cultures
Long-term single-cell passaging places hPSCs under significant selective pressure, increasing the risk of recurrent genetic abnormalities that can affect research outcomes. By using ±ð°Õ±ð³§¸éâ„¢, a medium specifically designed for hPSCs maintained as single-cell cultures, researchers can preserve genetic stability to achieve more reliable, reproducible gene editing, clonal expansion, and downstream differentiation workflows.
Publish Date:
July 31, 2023
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