Organoids in Drug Discovery
Predictive methods are needed to increase the chance of success in your drug programs before clinical trials. Organoids are a beneficial tool in drug discovery and toxicity testing, aiding target discovery, validation, and pre-clinical testing. Organoid models provide a more physiologically relevant cellular composition and tissue structure than standard 2D models, with increased accuracy and higher throughput, positioning them as a valuable component of new approach methodologies. Additionally, patient-derived organoids can be used to predict drug toxicity and efficacy, allowing you to make precise and confident decisions to advance your drug candidates.
Learn how organoids can help your drug-discovery workflow below.
Interview: The Role of Organoids and Organ-On-A-Chip Systems in Drug Discovery
Drs Bas Trietsch, Chief Technology Officer at MIMETAS, and Jenna Moccia, Director of Product Management at ƽ Technologies, discuss the challenges that lead pharma companies to adopt advanced in vitro models, such as organoids and organ-on-a-chip, and the benefits they see after incorporating these systems in their research.
Watch Now >- Dynamic Modeling in OrganoidsLearn more about organoid applications for studying human health
- Building Three-Dimensional Human Brain OrganoidsOverview of brain organogenesis and the applications of brain organoids in studying the development and maturation of the nervous system
- Initiating Intestinal Organoid Differentiation from Single-Cell hPSCs Using STEMdiff™<meta property="og:title" content="Using Single-Cell hPSCs for Intestinal Organoid Differentiation"/> <meta property="og:description" content="Want more control over your PSC cell populations for downstream differentiation? Check out our new protocol to learn how to prepare single cells for the use in intestinal organoid differentiations."/> <meta property="og:image" content="https://cdn.stemcell.com/media/images/social/PR00084-Intestinal-Organoid-Diff.jpg"/> <meta name="twitter:title" content="Using Single-Cell hPSCs for Intestinal Organoid Differentiation"/> <meta name="twitter:description" content="Want more control over your PSC cell populations for downstream differentiation? Check out our new protocol to learn how to prepare single cells for the use in intestinal organoid differentiations."/> <meta name="twitter:card" content="summary_large_image"/> <meta name="twitter:site" content="@ƽTech"/> <meta name="twitter:image" content="https://cdn.stemcell.com/media/images/social/PR00084-Intestinal-Organoid-Diff.jpg"/>
- Hepatic Organoids: Improved Tools and In Vitro Models for Drug DevelopmentThe HepatiCult™ Organoid Kit enables the differentiation, establishment, and maintenance of hepatic organoid cultures derived from human tissue. In this Innovation Showcase from ISSCR 2021, Charis Segeritz-Walko demonstrates how these organoids can be used as cutting-edge tools for drug development, highlighting new assays and protocols optimized to work with both 3D and 2D cultures. She will also compare the use of human hepatic organoids with common hepatic cell lines for analyzing drug responses.
