BMS 493

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Retinoid pathway activator; Activates pan-retinoic acid receptor

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BMS 493

Retinoid pathway activator; Activates pan-retinoic acid receptor

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Retinoid pathway activator; Activates pan-retinoic acid receptor

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Overview

BMS 493 is an inverse agonist of the pan-retinoic acid receptors (RARs). RARs are ligand-dependent transcription factors that regulate gene networks that control cell growth, differentiation, survival, and death (Germain et al.). BMS 493 has been shown to increase nuclear receptor co-repressor (NCoR) interaction with RARs (Germain et al.; Rinkevich et al.).

DIFFERENTIATION
· Affects development of bronchial tubule formation in mice (Chazaud et al.).

· Inhibits activation of immature dendritic cells (Geissmann et al.).

CANCER RESEARCH

· Inhibits differentiation of leukemic blasts (Kamashev et al.).

Airway Cells, Cancer Cells and Cell Lines, Hematopoietic Stem and Progenitor Cells, Monocytes

Human, Mouse, Non-Human Primate, Other, Rat

Differentiation

Cancer, Disease Modeling, Immunology, Stem Cell Biology

215030-90-3

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≥ 98%

Retinoid

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type

Product Name

Catalog #

Lot #

Language

Document Type

Product Name

Catalog #

73972, 73974

Lot #

All

Language

English

Document Type

Product Name

Catalog #

73972, 73974

Lot #

All

Language

English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Research Area

Workflow Stages

Workflow Stages for Airway Epithelial Cell Research

Expansion

Differentiation

Workflow Stages for Hematopoietic Stem and Progenitor Cell Research

Cell Sourcing and Isolation

Expansion and Differentiation

Analysis

Workflow Stages for Dendritic Cell Research

Sample Preparation

Cell Sourcing

Cell Isolation

Cell Differentiation and Maturation

Cell Characterization

Workflow Stages for Myeloid Cell Research

Sample Preparation

Cell Sourcing

Cell Isolation

Cell Differentiation & Maturation

Cell Characterization

Resources and Publications

Related Products

Quality Statement:

PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT ��ƽ��, REFER TO WWW.��ƽ��.COM/COMPLIANCE.

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BMS 493

Retinoid pathway activator; Activates pan-retinoic acid receptor

BMS 493

Retinoid pathway activator; Activates pan-retinoic acid receptor

Request Pricing

Overview

Protocols and Documentation

Applications

Resources and Publications

Educational Materials (4)

Related Products

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